Harvard College

Harvard Corporation

Mu-En Lee

Shaw-Fang Yet

Edgar Haber

Chung-Ming Hsieh

Mukesh Jain

Megan M McA'Nulty

Matthew D Layne

Jer-Chia Tsai

Zhou Fen

Winston Campbell Patterson

Mark A Perrella

Koji Maemura

The invention features a aortic carboxypeptidase-like polypeptide (ACLP), DNA encoding ACLP, and methods of detecting genetic alterations associated with abdominal wall defects.

Aortic carboxypeptidase-like polypeptide

The invention features a method of inhibiting hypertension in a mammal by administering to the mammal a compound that reduces expression or activity of SmLIM.

Methods of treating hypertension

Aortic-preferentially-expressed gene-1 (APEG-1) and striated muscle preferentially expressed (SPEG) polypeptide, DNA sequences encoding and controlling the transcription of the APEG-1/SPEG encoding gene, methods of diagnosing vascular injury, methods of conferring smooth muscle-cell specific expression, and methods of inhibiting vascular smooth muscle cell proliferation by increasing the level of APEG-1 at the site of vascular injury.

Striated-specific muscle cell polypetides

A method of inhibiting angiogenesis in a mammal by administering to the mammal a compound which inhibits binding of endothelial PAS domain protein-1 to cis-acting transcription regulatory sequence in the promoter region of a gene encoding an angiogenic factor.

Methods of modulating of angiogenesis

Aortic-specific enhancer sequence and uses thereof

The invention provides an isolated DNA which regulates vascular smooth muscle cell-specific transcription of a polypeptide-encoding sequence to which it is operably linked

Smooth muscle cell LIM promoter

A substantially pure DNA comprising a sequence encoding a smooth muscle cell LIM (SmLIM) polypeptide, methods of diagnosing vascular injury by detecting a decrease in SmLIM gene expression, and methods of inhibiting vascular smooth muscle cell proliferation.

Smooth muscle cell LIM protein

Disclosed is a novel mammalian protein designated repressor Kruppel-like factor (RKLF). RKLF is a zinc finger protein that binds to a CACCC element in DNA, thereby repressing gene transcription. An isolated DNA encoding RKLF, vectors and cells containing the DNA, and RKLF-specific antibodies are also disclosed. The RKLF DNA or protein can be introduced into the tissues of a mammal to inhibit neoplasia or hyperplasia. Also disclosed is an in vitro screening method for identifying a compound that induces RKLF gene expression.

Repressor Kruppel-like factor

Repressor kruppel-like factor

A substantially pure DNA comprising an endothelial cell-specific promoter sequence capable of directing endothelial cell-specific transcription of a polypeptide-encoding sequence or an antisense template to which it is operably linked.

Endothelial-cell specific promoter

The invention features a method of inhibiting sepsis-associated hypotension in a mammal which includes the steps of identifying a mammal suffering from or at risk of developing sepsis and administering to the mammal a compound which inhibits expression of inducible heme oxygenase (HO-1). Also disclosed are screening assays useful for identifying a compound capable of inhibiting HO-1 expression or enzymatic activity.

Regulation of vascular smooth muscle cell heme oxygenase-1

Single gene encoding aortic-specific and striated-specific muscle cell

An aortic-preferentially-expressed gene-1 (APEG-1) polypeptide, DNA sequences encoding and controlling the transcription of APEG-1, methods of diagnosing vascular injury, and methods of inhibiting vascular smooth muscle cell proliferation by increasing the level of APEG-1 at the site of vascular injury.

Growing community of inventors

Newton, MA, United States of America

Mu-En Lee