Pfizer Corporation

Moustafa Marc Hamze

Barbra Johnson Sasu

Yik Andy Yeung

Cesar Adolfo Sommer

Danielle Elizabeth Dettling

Provided herein are antibodies that specifically bind to Fms-like tyrosine kinase 3 (FLT3), chimeric antigen receptors (CARs) that specifically bind to FLT3, and engineered immune cells expressing such CARs (e.g. FLT3-specific CAR-T cells). The invention also provides making such antibodies, CARs, and engineered immune cells. The invention also provides using such antibodies, CARs, and engineered immune cells, for example for the treatment of a condition associated with malignant cells expressing FLT3 (e.g., cancer).

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Nogent-sur-Marne, France

Moustafa Marc Hamze