University of Iowa Research Foundation

Moustafa Gabr

Michael K Schultz

Mengshi Li

Christopher Pigge

Edwin Sagastume

A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I): or a salt thereof wherein: each of R-Ris independently selected from the group consisting of CHCOORand CHC(═O)NHR; each of R-Ris independently selected from the group consisting of H and -L-X; each Ra is independently selected from the group consisting of H and -L-X; each L is independently selected from the group consisting of absent and a linking group; and each X is a biological agent; and wherein the contacting occurs at a temperature below about 40° C. to form a chelated composition.

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Iowa City, IA, United States of America

Moustafa Gabr