Sanofi-aventis

Mitsubishi Pharma Corporation

Sanofi

Mitsubishi Tanabe Pharma Corporation

Mitsubishi Electric Corporation

Tanabe Pharma Corporation

Mitsubishi Pharma Corporation Tokyo

Mourad Saady

Alistair Lochead

Philippe Yaiche

Franck Slowinski

Julien Vache

Aude Fayol

Thierry Gallet

Alain Nedelec

Nathalie Chereze

Corinne Veronique

Ahmed Abouabdellah

Patrick Andre Lardenois

Séverine Marguerie

Antonio Almario Garcia

Adrien Tak Li

Pascal George

Omar Ben Ayad

Odile LeClerc

Odile Leclerc

A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein X, R1, R2, R3, R4, and m are defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I), intermediates thereof and their use in therapeutics.

Substituted alkyl pyrimidin-4-one derivatives

Pyrimidone derivatives of formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I) and their use in therapeutics.

Substituted pyrimidone derivatives

The invention relates to a compound of the general formula (I) in which Ris a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C-alkyl, C-alkoxy, NRRgroup; m, n, o and p are independently an integer equal to 0, 1, 2 or 3; A is a covalent bond or a C-alkylene group; Ris an optionally substituted aryl or heteroaryl group; Ris a hydrogen or fluorine atom or a C-alkyl group or a trifluoromethyl group; Ris an optionally substituted 5-member heterocyclic compound; the compound being in the form of a base or acid addition salt. The invention also relates to the therapeutic use thereof. 

Derivatives of azaspiranyl-alkylcarbamates of 5-member heterocyclic compounds, preparation thereof and therapeutic use thereof

The invention relates to compounds of the general formula (I) where: Ris a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C-alkyl, C-alkoxy, or NRRgroup; m and p have a value of 1; n and o have the same value which is 0 or 1; A is a covalent bond or a C-alkylene group; Ris an optionally substituted aryl or heteroaryl group; Ris a hydrogen or fluorine atom or a C-alkyl group or a trifluoromethyl group; Ris an optionally substituted 5-membered heterocyclic compound; wherein the compounds can be in the state of a base or an acid addition salt. The present invention can be used in therapeutics. 

5-membered heterocyclic compound cyclopenta[C]pyrrolylalkylcarbamate derivatives, preparation thereof, and therapeutic use thereof

The invention relates to compounds of the general formula (I): wherein R, m, n and o are as defined herein. The invention also relates to a method for preparing the same and to the application in therapy.

Azabicycloalkane derivatives, preparation thereof and use thereof in therapy

Compound corresponding to general formula (I): in which Ris a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C-alkyl, C-alkoxy or NRRgroup; n is an integer equal to 1, 2 or 3 and m is an integer equal to 1 or 2; A is a covalent bond or a C-alkylene group; Ris a phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, naphthyl, quinolinyl, isoquinolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, cinnolinyl or naphthyridinyl group, this group being optionally substituted; Ris a hydrogen or fluorine atom, a C-alkyl group or a tritluoromethyl group; Ris a group selected from furanyl, pyrrolyl, thienyl, isothiazolyl, oxazolyl, isoxazolyl, pyrazolyl, oxadiazolyl, thiadiazolyl, imidazole, triazolyl, tetrazolyl, oxazolone, oxazolidinone, isoxazolone, isoxazolidinone, isothiazolone, isothiazolidinone, imidazolone, imidazolidinone, pyrazolone, pyrazolidinone, oxadiazolone, thiadiazolone and triazolone, this group being optionally substituted; in the form of a base or of an addition salt with an acid. Therapeutic use. 

Carbamate derivatives of alkyl-heterocycles, preparation thereof and therapeutic use thereof

A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein Y, R1, R2, R3, and R4 are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I), intermediates thereof and their use in therapeutics.

Substituted pyrimidin-4-one derivatives

The present invention discloses a series of pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof:  Wherein X, Z, R1, R2, R3, R4, R5, R6, R7, n and m are as defined herein. Also disclosed herein are the methods of preparation of compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.

Arylamide pyrimidone compounds

The present invention discloses a series of pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: Wherein X, Z, R1, R2, R3, R4, R5, R6, R7, n and m are as defined herein. Also disclosed herein are the methods of preparation of compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.

Heteroarylamide pyrimidone derivatives

Arylamide pyrimidone derivatives

Heteroarylamide pyrimidone compounds

Triazinone derivatives represented by formula (I) wherein:

Substituted triazinone derivatives

The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein:Y, Z, R1, R2, R3, R4, R5 and n are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.

Substituted arylamide diazepinopyrimidone derivatives

The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein:

Substituted arylamide oxazepinopyrimidone derivatives

The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: 

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Paris, France

Mourad Saady