Nanyang Technological University

Menicon Co., Ltd.

Mouad Lamrani

Shinichi Hamaguchi

Chan Bee Eng Mary

Poon Yin Fun

Shoji Ichinohe

Toshio Yamazaki

Tsuyoshi Watanabe

Bee Eng Mary Chan

Eri Ito

Matthew Wook Chang

Sadayasu Tanikawa

Peng Li

Chuncai Zhou

Susanna Su Jan Leong

Xiaobao Qi

A contact lens includes a glucose sensor which can determine when a detectable concentration of glucose is present in the optical fluids of the user. The glucose sensor can transition between a first state and a second state relative to the concentration of glucose within the optical fluid of the user. The glucose sensor can be bonded or otherwise attached or incorporated into the contact lens. While the contact lens is worn in the user's eye, either the user or another person can view the contact lens to quickly determine if an excessive amount of glucose is present in the user's system.

Glucose sensing contact lens

The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes. In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices. This invention describes the formation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence providing hydrogels as antimicrobial water shield coating agent.

Chitosan hydrogel derivatives as a coating agent with broad spectrum of antimicrobial activities

An object of the present invention is to provide a polymerizable composition capable of providing antimicrobial properties to ophthalmic and medical devices relatively inexpensively with ease, and an antimicrobial composition obtained by polymerizing the polymerizable composition. A polymerizable composition for ophthalmic or medical use comprising an epsilon-polylysine having (meth)acryloyl group is provided. The content of the epsilon-polylysine having (meth)acryloyl group in the polymerizable composition is preferably about 0.1 to 99% by weight, based on the whole amount of the composition. A coating agent for ophthalmic or medical use comprising the above polymerizable composition, an antimicrobial composition for ophthalmic or medical use obtained by polymerizing the above polymerizable composition, an ophthalmic or medical device comprising the antimicrobial composition, and a contact lens comprising the antimicrobial composition are also provided.

Polymerizable composition for ophthalmic and medical use and antimicrobial composition obtained by polymerizing the polymerizable composition

Process for preparing ocular lens with urethane compound and process for preparing urethane compound for medical instruments

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Lyons, France

Mouad Lamrani