Asahi Kasei Pharma Corporation

Asahi Kasei Kabushiki Kaisha

Motoshi Shoda

Hiroshi Kuriyama

Naoyuki Ishii

Yuichi Arimoto

Hiromichi Itoh

Toshinori Ishizuya

In the case of using 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phenyl]propionic acid, methyl 3-[4-(indan-2-yloxy)-3-(1-methyl-1H-indazol-5-yl)-5-nitrophenyl]propionate, or methyl 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phenyl]propionate as a medicine, more preferable aspects or improved methods are provided. Crystals of any compound among 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phenyl]propionic acid, methyl 3-[4-(indan-2-yloxy)-3-(1-methyl-1H-indazol-5-yl)-5-nitrophenyl]propionate, and methyl 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phenyl]propionate, and methods of producing the same are provided.

Crystal of substituted phenylalkanoic acid ester and process for producing the same

Crystals of substituted phenylalkanoic acid and method of producing the same

Crystal forms of substituted phenylalkanoic acids and process for producing the same

A compound represented by the general formula (I) or a salt thereof: [T represents oxygen atom and the like; V represents CHand the like; Rto Rrepresent hydrogen atom and the like; A represents a linear alkylene group or linear alkenylene group having 2 to 8 carbon atoms and the like; D represents carboxyl group and the like; X represents ethylene group, trimethylene group and the like; E represents &#x2014;CH(OH)&#x2014; group and the like; and W represent &#x2014;U&#x2014;(R)(R)&#x2014;U&#x2014;Ugroup (Urepresents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; Rand Rrepresent hydrogen atom and the like; Urepresents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; and Urepresent an alkyl group having 1 to 8 carbon atoms and the like), or a residue of a carbon ring or heterocyclic compound], which can be utilized as an active ingredient of medicaments effective for prophylactic and/or therapeutic treatment of skeletal diseases such as osteoporosis and fracture, glaucoma, ulcerative colitis and the like.

6-Membered heterocyclic compound and use thereof

A compound represented by the formula (I): [In the formula, Link represents a saturated or unsaturated straight hydrocarbon chain having 1 to 3 carbon atoms, Cto Cin the aromatic ring (E) independently represent a ring-constituting carbon atom, one of the ring-constituting carbon atoms may be replaced with V, V represents nitrogen atom, or carbon atom substituted with Zx, Zx represents a saturated alkyl group having 1 to 4 carbon atoms and the like, Rs represents -D-Rx etc., D represents a single bond, oxygen atom and the like, Rx represents a saturated alkyl group having 3 to 8 carbon atoms and the like, AR represents a partially unsaturated or completely unsaturated condensed bicyclic carbon ring or a heterocyclic ring, and Y represents hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms and the like] or a salt thereof. A compound having prostaglandin production-suppressing action and leukotriene production-suppressing action is provided.

Substituted arylalkanoic acid derivatives and use thereof

A compound represented by the formula (I) or a salt thereof:wherein n represents an integer of 1 to 3, R represents an alkyl group having 3 to 8 carbon atoms, a group represented by the following formula: R(CH)&#x2014; (wherein k represents 0 or an integer of 1 to 3; Rrepresents a saturated cyclic alkyl group having 3 to 7 carbon atoms or a saturated condensed cyclic alkyl group having 6 to 8 carbon atoms, and the group Rmay be substituted with a lower alkyl group having 1 to 4 carbon atoms) and the like, and Ar represents a condensed bicyclic group such as naphthalen-1-yl group, which has suppressing action on prostaglandin and leukotriene production and is useful for prophylactic and/or therapeutic treatment of various inflammatory diseases and the like caused by these lipid mediators.

Growing community of inventors

Tokyo, Japan

Motoshi Shoda