Daikin Industries, Ltd.

Otsuka Pharmaceutical Company, Limited

Motoshi Matsui

Takashi Nomura

Nipun Davar

Masato Naitou

Masahiro Miyake

Kimiyoshi Annaka

Gemma Zuend

Ian Scott

Hideyuki Ikeuchi

Yosuke Kishikawa

Naoyuki Hoshiya

A fluoropolyether group-containing silane compound of the formula (1a) or the formula (1b), the symbols of which are as defined herein:R—X—R  (1a)R—X—R—X—R  (1b).

Fluoropolyether group-containing silane compound

A fluoropolyether group-containing compound of formula (1a) or formula (1b): wherein R, R, Rand Rare as defined herein.

Fluoropolyether group-containing compound

An object of this disclosure provides a novel method for producing a fluorovinyl amide compound and the like. The object is achieved by a method for producing a compound represented by formula (1): whereinRf is —F or fluoroalkyl,Ris —H or an organic group, andRis —H or an organic group, or(i) Rand R, (ii) Rand Rf, or (iii) Rf and R, may be linked to each other,Ris —H or an organic group, andRis —H or an organic group, orRand Rmay be linked together with their adjacent atoms to form a nitrogen-containing ring optionally having one or more substituents,the method comprisingstep A of reacting a compound represented by formula (2): whereinRis a leaving group,with a compound represented by formula (3) or a salt thereof: in the presence of a transition metal catalyst.

Method for producing fluorovinyl amide compound

The invention relates to methods of synthesizing 2'-deoxy-2′,2′-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.

2'-deoxy-2′,2′-difluorotetrahydrouridines with high purity and methods of making the same

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Osaka, Japan

Motoshi Matsui