Takasago International Corporation

Motonobu Takenaka

Tsukasa Sotoguchi

Hideki Nara

Kazuhiko Matsumura

Kenji Yagi

Toshiyuki Murayama

Tohru Yokozawa

Wataru Kuriyama

Takashi Moroi

Takashi Miura

Takaji Matsumoto

Disclosed is an industrially advantageous production method of optically active &#x3b2;-amino acid of formula (5), which includes subjecting an enaminoester of formula (4) to an asymmetric hydrogenation: 

Method for producing an optically active tetrahydroquinoline

The present invention provides an industrially advantageous production method of optically active tetrahydroquinolines of formula (1), which comprises:      

An object of the present invention is to provide a process for producing optically active 3-quinuclidinol having high optical purity or the salt thereof at high yield. The invention relates to a process for producing optically active 3-quinuclidinol or the salt thereof by reacting 3-quinuclidinone or the salt thereof with hydrogen in the presence of a basic compound, a complex of a transition metal in Groups 8 to 10, an optically active bidentate ligand and an optically active diamine.

Process for producing optically active-3-quinuclidinols

Process for producing optically active &ggr;-butyrolactone

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Hiratsuka, Japan

Motonobu Takenaka