Hitachi Software Engineering Company, Ltd.

Motonao Nakao

Keiichi Sato

Mitsuhiro Tachibana

Toshiki Morita

Kenji Yamamoto

Junji Yoshii

Katsuya Mizuno

A method for reading beads comprising the steps of: introducing into a flow path functional beads having a coating layer on the surface thereof and having nanoparticles present in the coating layer; enabling the functional beads to emit light specific to the nanoparticles by applying a voltage to the functional beads in the flow path; and identifying the functional beads based on the emission. A bead-reading apparatus employing the method is also disclosed. Since conventional fluorescent beads are excited with a laser for reading fluorescence, light leakage occurs, so that the influence of noise cannot be ignored. The invention eliminates this drawback.

Functional beads, method for reading the same and bead-reading apparatus

Provided is an apparatus for detecting biopolymers (DNA) capable of total analysis including non-reacted samples without complicated operations such as washing. A DNA probe is fixed to one of electrodes and direct current voltage is placed between the electrodes, so that it becomes possible to separate complementary strand sample DNA and non-complementary strand sample DNA. By analyzing from a ratio in the whole reaction system, it is possible to obtain clearer results. Further, by using electrophoresis by gel together, it is possible to separate reacted samples and non-reacted samples to perform measurements therefor in the same reaction field.

Apparatus for detecting biopolymers and cartridge

The present invention detects and quantities only specific hybridization bindings. A biochip which is spotted with a plurality of probe biopolymers is accommodated in a container into which a washing solution is supplied from a liquid supplying unit . A heat block controls the temperature of the biochip according to a predetermined time pattern. A pickup unit picks up an image of the spot surface of the biochip at predetermined pickup intervals. The plurality of images picked up with the pickup unit are stored in a computer . By analyzing the images for individual spots, hybridization can be detected with high reliability for every spots without being influenced by optimal hybridization temperatures which differ depending upon the types of probes on the spots.

Method and device for detecting hybridization reaction

Disclosed is a biopolymer (DNA) detector capable of performing overall analysis including an unreacted sample without needing any complex work such as washing or the like. A DNA probe is fixed to an electrode plate and the electrode plate is displaced by applying a DC voltage between electrode plates and Thus, sample DNA to be detected can be separated. It becomes possible to obtain a clearer result by performing analysis based on a ratio of an entire reaction system.

Growing community of inventors

Kanagawa, Japan

Motonao Nakao