Taisho Pharmaceutical Co., Ltd.

Motoko Oshida

Takaaki Ishii

Joji Sasaki

Hiroaki Kamiyama

Mitsuaki Hirotsuka

Production of a bicyclo[3.1.0]hexane derivative, useful as a metabotropic glutamate receptor modulator, becomes possible by a production method that includes converting a compound represented by Formula (II) into a compound represented by Formula (III) by reaction with an acyl group donor in the presence of a microorganism-derived enzyme, without using an expensive optically active trans hydroxy ester as a starting material and without employing a fluorination reaction requiring an ultralow temperature reaction. Furthermore, since asymmetric synthesis can be carried out in a stage closer to the final product, the production method is useful as a production method that can mass produce a bicyclo[3.1.0]hexane derivative. 

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Tokyo, Japan

Motoko Oshida