Showa Denko K.k.

Motoki Murai

Akira Shibuya

Hideo Miyata

Takanori Aoki

Takamitsu Kobayashi

Manabu Kuwajima

Shinya Tsukamoto

Provided is a method for producing an orotic acid derivative, the method comprising a condensation step of performing, under a basic condition, a condensation reaction between an orotic acid halide represented by General Formula (I) and a compound represented by General Formula (II) to generate an orotic acid derivative represented by General Formula (III); and a neutralization crystallization step of precipitating crystals of orotic acid by neutralization crystallization to separate a liquid containing the orotic acid derivative from the crystals of orotic acid, after the condensation step. In General Formula (I), (II), or (III), X is a halogen atom, and A is a group represented by General Formula (A-1) or (A-2). In General Formula (A-1) or (A-2), Ris a hydrogen atom or an organic group, and Rand Rare each independently an organic group. In a case where Ris an organic group, Rand Rmay be bonded to each other to form a ring. 

Method for producing orotic acid derivative

Provided is a method for producing glycine, in which on synthesizing glycine from glycinonitrile, glycine can be obtained in a higher yield than that in the conventional method. The present invention relates to a method for producing glycine, including allowing glycinonitrile and water to react with each other in the presence of a cerium compound, optionally adding ammonia thereto, to obtain glycine.

Method for producing glycine

The present invention relates to a method for producing a specified &#x3b1;-amino acid, the method including allowing a specified &#x3b1;-amino acid amide and water to react with each other in the presence of a zirconium compound which contains zirconium and at least one metal element selected from the group consisting of lithium, nickel, copper, zinc, cesium, barium, hafnium, tantalum, cerium, and dysprosium.

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Tokyo, Japan

Motoki Murai