Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kirin Co., Limited

Motoki Miyama

Yutaka Kanda

Yukimasa Shiotsu

Fumihiko Kanai

Tomoki Naoe

Hitoshi Kiyoi

Shinji Nara

Yoshihisa Ohta

Hiroshi Umehara

Keiko Kawashima

Hiromi Ando

Etsuo Ohshima

Ichiro Miki

Hitoshi Arai

Satoshi Nakanishi

Kimihisa Ueno

Seiji Aratake

Koji Suzuki

Koji Yanagawa

Hiroshi Ishida

Tsutomu Matsumura

Katsuya Kobayashi

Yosuke Yamaura

Ari Kawabe

Takashi Sato

Shinya Fujii

Miho Iwase

The present invention provides a compound represented by Formula (I): [wherein Rrepresents CONRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or Rand Rare combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like,Rrepresents a hydrogen atom, CONRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or Rand Rare combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroaroyl, substituted or unsubstituted ararkyl, substituted or unsubstituted lower alkylsulfonyl or substituted or unsubstituted lower arylsulfonyl) or the like].

Indazole derivatives

[wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; Rrepresents &#x2014;NRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); Rrepresents the above Formula (II), Formula (IV) or the like; A represents a single bond, &#x2014;C(&#x2550;O)&#x2014;, &#x2014;SO&#x2014;, &#x2014;OC(&#x2550;O)&#x2014; or the like; and Rrepresents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like] Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided. These have anti-inflammatory activities or modulation activities on the functions of TARC and/or MDC and are useful for treating and/or preventing a disease which is related to T cells, such as an allergic disease, an autoimmune disease or transplant rejection.

Bicyclic pyrimidine derivatives

The present invention provides a compound represented by Formula (I): [wherein Rrepresents CONRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or Rand Rare combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like,

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Sunto-gun, Japan

Motoki Miyama