Osaka University

Kyoto University

Inter-university Research Institute Corporation National Institutes of Natural Sciences

Rdiscovery, LLC

Motohiro Nishida

Akio Ojida

Yasuo Mori

Masayuki Mori

Ryu Nagata

Takuro Tomita

Naoya Shindo

Akiyuki Nishimura

Compounds represented by formula (I) below and pharmacologically acceptable salts thereof and solvates of them; pharmaceutical compositions and dynamin-related protein 1 (Drp1)-filamin complex formation inhibitors containing them; and uses of the compounds, salts, solvates, pharmaceutical compositions, and (Drp1)-filamin complex formation inhibitors for use as a prophylactic or therapeutic agent.

Drp1-filamin complex formation inhibitors

The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1) (wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom,ofY is a single or double bond when Y is a carbon atom, orofY is a single bond when Y is a nitrogen atom; each Rindependently represents lower alkyl, or two Rs may be bound to each other to form a spiro ring or a crosslinked structure, or two Rs may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R)is oxo).

Benzisoxazole compound

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Aichi, Japan

Motohiro Nishida