Tokyo University of Marine Science and Technology

Kawasaki Jukogyo Kabushiki Kaisha

Denka Company Limited

Director-general of National Institute of Infectious Diseases

Nippon Steel Sumitomo Metal Corporation

Tokyo Institute of Technology

The Kitasato Institute

National Center for Geriatrics and Gerontology

Kitano Seiki Co., Ltd.

Nippon Steel Corporation

Japan As Represented by the Director-general of National Institute of Infectious Diseases

National University Corporation Tokyo University of Marine Science and Technology

Japan As Represented by Director General of Agency of National Institute of Infectious Deseases

Motohiro Miki

Mitsuru Izumi

Kazuhiko Katayama

Kota Yamaguchi

Toshiyuki Yanamoto

Yohei Murase

Etsuya Yanase

Reiko Todaka

Akira Fujimoto

Hiroshi Otsuka

Mitsuru Morita

Yoshimasa Takahashi

Masahiro Kitano

Hidekazu Teshima

Sakari Sekine

Takafumi Ueno

Shigetaka Mimori

Kengo Yoshikawa

Megumi Mano

Taishi Onodera

Kei Haga

Akira Nakanishi

Ueno Takafumi

Yoshikawa Kengo

Mano Megumi

The present invention addresses the issue of providing a norovirus component vaccine for subcutaneous, intradermal, percutaneous, or intramuscular administration which vaccine can readily immunize the target cells, an associated product of a molecular needle serving as an active ingredient of the vaccine, and a production method for the associated product. The invention provides a norovirus component vaccine containing, as an active ingredient, an associated product including a hexamer formed through bonding of two molecules of a trimer of a molecular needle represented by the following formula (1). W-L-X&#x2014;Y (1) [wherein W represents an amino acid sequence of P domain of the capsid protein of norovirus as an immunogen; Lrepresents a first linker sequence having 0 to 100 amino acids; X represents an amino acid sequence represented by SEQ ID NO: 1; Y represents an amino acid sequence of a cell introduction domain; n is an integer of 1 to 3].

Composite polypeptide monomer, aggregate of said composite polypeptide monomer having cell penetration function, and norovirus component vaccine for subcutaneous, intradermal, percutaneous, or intramuscular administration and having said aggregate as effective component thereof

A radial-gap type superconducting synchronous machineis prepared which includes a rotorhaving, on its peripheral side, a convex magnetic polewhich includes, at its distal end part, bulk superconductors. When viewed in the direction of the rotational axis Cof the rotor, the magnetic pole center side of the bulk superconductorsis disposed nearer to a statorthan the magnetic pole end side of the bulk superconductors. A ferromagnetis disposed on the rotational axis Cside of the bulk superconductors. A magnetizing apparatusis disposed outside the bulk superconductorsin the radial direction of the rotor. Magnetization of the bulk superconductorsis performed by directing magnetic flux lines from the magnetizing apparatustoward the bulk superconductors

Radial-gap type superconducting synchronous machine, magnetizing apparatus, and magnetizing method

An object of the present invention is to solve problems in terms of stagnation of research on norovirus by providing a cultured transgenic cell or a transgenic animal in which murine norovirus (MNV) can be grown across the barrier of host specificity in mammalian cells, and providing a screening method that uses the cultured transgenic cell or the transgenic animal. The present inventors have found that MNV infection is determined in a cultured transgenic mammalian cell or a mammal possessing the cultured transgenic mammalian cell as its own cell, the cultured transgenic mammalian cell containing one or more species selected from the entirety or a portion of the murine CD300F gene and/or a CD300 family gene having an extracellular domain nucleotide sequence similar to that of the murine CD300F gene. The present inventors have solved the aforementioned problems by providing, for example, a norovirus-related drug screening method on the basis of this finding.

Cultured transgenic cell allowing growth of norovirus, and use thereof

A radial-gap type superconducting synchronous machineis prepared which includes a rotorhaving, on its peripheral side, a convex magnetic polewhich includes, at its distal end part, bulk superconductorsWhen viewed in the direction of the rotational axis Cof the rotorthe magnetic pole center side of the bulk superconductorsis disposed nearer to a statorthan the magnetic pole end side of the bulk superconductorsA ferromagnetis disposed on the rotational axis Cside of the bulk superconductorsA magnetizing apparatusis disposed outside the bulk superconductorsin the radial direction of the rotorMagnetization of the bulk superconductorsis performed by directing magnetic flux lines from the magnetizing apparatustoward the bulk superconductors

Radial-gap type superconducting synchronous machine, magnetizing apparatus and magnetizing method

A rotary machine cools a cooling target inside a rotor rotatable around a rotational axis, includes a condenser section disposed outside the rotor and condenses a gas phase cooling medium into a liquid phase cooling medium; an evaporator section disposed inside the rotor, and evaporates the liquid phase cooling medium generated by condensation in the condenser section into the gas phase cooling medium, by heat exchange between the cooling target and the liquid phase cooling medium; and a coupling pipe flows the liquid phase cooling medium and the gas phase cooling medium between the evaporator section and the condenser section, wherein the coupling pipe has a pipe structure in which a liquid phase cooling medium passage flows the liquid phase cooling medium generated by the condensation in the condenser section and a gas phase cooling medium passage flows the gas phase cooling medium generated by evaporation in the evaporator section.

Rotary machine

Provided is a rotary machine capable of increasing cooling efficiency while preventing an increase in the weight and cost of a rotor even in a case where the diameter of the rotor is increased. A rotary machine including a rotor which is rotatable around a rotational axis, and a cooling device, wherein the rotor includes: a hollow cooling medium flow section provided in a center portion of the rotor in a radial direction and extending along the rotational axis; and a cooling target provided outward of the cooling medium flow section in the radial direction, and the rotary machine comprises a stationary section pipe which introduces a liquid phase cooling medium generated by cooling in the cooling device into the cooling medium flow section, and returns a gas phase cooling medium present in an inside of the cooling medium flow section from the cooling medium flow section toward the cooling device, the rotor including: a leading passage which leads the liquid phase cooling medium to a region which is in the vicinity of the cooling target through a first opening formed in a side surface of the cooling medium flow section, the side surface extending along the rotational axis; and a return passage which returns the gas phase cooling medium to the inside of the cooling medium flow section, the gas phase cooling medium being generated by evaporation of the liquid phase cooling medium in the region which is in the vicinity of the cooling target, by heat exchange between the liquid phase cooling medium and the cooling target.

A superconducting bulk magnet comprising a plurality of superconducting bulk materials combined, in which breakage of superconducting bulk materials is prevented and a strong magnetic field can be generated, that is, a superconducting bulk magnet comprising a plurality of superconducting bulk materials, each comprising a single-crystal formed REBaCuO(RE is one or more elements selected from Y or rare earth elements, where 6.8&#x2264;y&#x2264;7.1) in which REBaCuOis dispersed and each provided with a top surface, a bottom surface, and side surfaces, combined together, in which superconducting bulk magnet, bulk material units, each comprising a superconducting bulk material and a bulk material reinforcing member arranged so as to cover a side surface of the same, are arranged facing the same direction and contacting each other to form an assembly, a side surface of the assembly is covered by an assembly side surface reinforcing member, a top surface and bottom surface of the assembly are respectively covered by an assembly top reinforcing member and an assembly bottom reinforcing member, and the assembly side surface reinforcing member, the assembly top reinforcing member, and the assembly bottom reinforcing member are joined into an integral unit, is provided.

Oxide superconducting bulk magnet

A joint includes a housing and a refrigerant tube connected to a refrigerant source and communicated with a target part in a rotating machine. A rotating member is loosely fitted inside with the refrigerant tube and fixed to a rotary part of the rotating machine. A relatively rotating member has a fixed-side member and rotating-side member. The fixed-side member is connected to the refrigerant tube via a refrigerant tube extension section. The rotating-side member is connected to the rotating member via a rotating member extension section. A refrigerant zone is formed by spaces defined between the refrigerant tube and the rotating member, and between the refrigerant tube and rotating member extension sections. A sealing member is installed between the fixed-side and rotating-side members. A vacuum chamber and pressure chamber are defined within the housing.

Cryo-rotary joint

Growing community of inventors

Tokyo, Japan

Motohiro Miki