Snow Brand Milk Products Co., Ltd.

Motohide Seya

Susumu Ishiguro

Shin Nomoto

Shinichi Shimada

Masayuki Okue

Yuzo Yagi

Nobuo Ogane

Masamichi Nakakoshi

Yasuyoshi Takeshita

Shin'ichi Shimada

Noboru Kawaguchi

Tadayoshi Koyama

Hiroshi Nakamura

Noboru Kwaguchi

Noriko Abe

Naomi Kito

Kunio Tomitsuka

Yasunari Saito

Yasunari Saitou

Isoquinoline derivatives

Particular hexahydropyrano [3,2-b] [1,4] benzothiazine derivatives represented by the following general formula (I) or pharmaceutically acceptable acid-addition salts thereof. ##STR1## The compounds can facilitate the metabolic turnover of inositol phospholipids at a hippocampus playing an important part in memory, and improve cerebral function leading the memory. The compounds can be utilized as agents for activating brain metabolism and improving cerebral function.

Hexahydropyrano [3,2-B] [1,4] benzothiazine derivative

The invention provides novel compounds and salts thereof, have the structure ##STR1## wherein R.sub.1 is a guianidinobenzoyloxy group and R.sub.2 is a hydrogen atom, a hydroxy, cyano, --COR.sub.3 (wherein R.sub.3 is an amino or lower alkyl group) or --COOR.sub.4 group [wherein R.sub.4 is a hydrogen atom, lower alkyl, phenyl, benzyl or --CH.sub.2 CONR.sub.5 R.sub.6 group (wherein R.sub.5 and R.sub.6 are the same or different and selected from a hydrogen atom and lower alkyl groups)], and wherein R.sub.1 is a hydroxy group and wherein R.sub.2 is a --COR.sub.3 (wherein R.sub.3 is an amino or lower alkyl group) or --COOR.sub.4 group [wherein R.sub.4 is a (C.sub.1, C.sub.3 or C.sub.4) alkyl, phenyl, benzyl or --CH.sub.2 CONR.sub.5 R.sub.6 group (wherein R.sub.5 and R.sub.6 are the same or different and selected from a hydrogen atom and lower alkyl groups)]. The compounds, wherein R.sub.1 is a guanidinobenzoyloxy group, are useful protease inhibitors as anti-trypsin agents.

Isoquinoline derivatives and salts thereof

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Tochigi-ken, Japan

Motohide Seya