Km Biologics Co., Ltd.

Motoharu Abe

Kazuhiko Kimachi

Kazuyuki Ikeda

Hiroto Onuma

Yukari Tsurudome

Kiyoto Nishiyama

Ryo Yamaue

Daisuke Ikeno

Shinichi Maruno

Yusuke Ooyama

Ryoichi Kitano

Kengo Sonoda

Yuki Ohara

Yasuhisa Hayashi

Masaya Yoshimura

Tatsufumi Onchi

Issay Asano

Shota Takagi

Kazuhisa Kameyama

Akihiro Watanabe

Fusae Komura

Aki Fukuda

Susumu Yamaori

Yasuhiko Shinmura

Naomi Uchida

The present invention relates to a vaccine containing fixed virus particles, wherein a summed fever response of three rabbits to the fixed virus particles in a pyrogen test is less than 80% based on a summed fever response of three rabbits to original virus particles of the fixed virus particles or corresponding inactivated virus particles.

Vaccine containing immobilized virus particles

A highly safe dengue vaccine was invented that induced a neutralizing antibody response against all of the four serotypes of dengue virus without developing more than a fixed level of viremia with single administration. A tetravalent dengue virus formulation is provided that is excellent in both efficacy (neutralizing antibody response) and safety (viremia).

Multivalent dengue vaccine composition comprising a mixture of attenuated dengue viruses from different serotypes

The present invention provides a vaccine containing virus-like particles derived from virus particles having an envelope, in which a lipid-component content of the virus-like particles is reduced relative to a lipid-component content of the virus particles.

Vaccine containing virus-like particles

Growing community of inventors

Kikuchi, Japan

Motoharu Abe