Fujisawa Pharmaceutical Company, Ltd.

Motoaki Nishikawa

Sumio Kiyoto

Masakuni Okuhara

Shigehiro Takase

Satoshi Okada

Masanobu Kohsaka

Masami Ezaki

Tohru Kino

Morita Iwami

Nobuharu Shigematsu

Keiji Hemmi

Hiroshi Terano

Keizo Yoshida

Nobutaka Oohata

Hidetsugu Murai

The novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof have useful pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain. A method for the production of the peptides WS-9326A and WS-9326B and derivatives thereof using Streptomyces violaceoniger No. 9326 in a biologically pure form is described herein.

Process for producing WS-9326A and WS-9326B

This invention relates to the novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof which have pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain.

Peptides WS-9326a and WS-9326b, derivatives thereof and uses thereof

Anthraquinone compounds of the formula: ##STR1## wherein: R.sup.1 is hydrogen, hydroxy or acyloxy,

Anthraquinone derivatives and preparation thereof

This invention relates to a biologically active WS-7739-A substance and a biologically active WS-7739-B substance which have pharmacological activities and are useful for the treatment of asthma, thrombosis and the alike.

WS 7739 substances, their preparation and pharmaceutical composition

Novel compounds designated as WS 6049-A and WS 6049-B are disclosed, as well as compositions containing the compounds thereof, a method of treating microbial infections, a method of prolonging the survival time of the patient with lymphocytic leukemia by administering the compounds thereof, and a process for making the WS 6049 substances, are disclosed. As indicated above, the novel compounds have antimicrobial and antileukemic activities which make them useful against a variety of pathogenic microorganisms and leukemic tumors.

Biologically active WS 6049 substances, a process for the production

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Tsukuba, Japan

Motoaki Nishikawa