Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

Mose Santaniello

Maria Ornella Tinti

Domenico Misiti

Piero Foresta

Nazareno Scafetta

Antonio Longo

Claudio Cavazza

Aleardo Koverech

Carlo A Bagolini

Nicola Pescosolido

Nicola Fanto

Giulio Taglialatela

Marie O Tinti

Paola Risi

Silverio Fontana

Agostino Uttaro

The present invention relates to a solid powder composed of a mixture of a natural or a synthetic polymer which forms a gel, a buffer, such as an hydroxyacid or a dicarboxyacid, a saccharide, one or more drugs useful for the treatment of diseases of the eyes and optionally one or more excipients and/or regulators of the osmotic pressure ophthalmologically acceptable.

Gel useful for the delivery of ophthalmic drugs

A gel, for cosmetic use, composed of a mixture of a polymer which forms a gel, a surfactant, and propionyl L-carnitine glycinate hydrochloride, useful for treating disturbances of the skin such as cellulite and wrinkles is described.

Gel useful for the delivery of cosmetic active ingredients

Solid compositions suitable for oral administration comprising

A process for making valproic acid from an alkyl alkanoylacetate is disclosed. The alkyl alkanoylacetate is reacted with an n-propyl halide in a biphasic system in the presence of a base and a phase transfer catalyst. The product mixture is acidified to convert the resulting valproate salt into valproic acid.

Process for producing valproic acid

Esters of acyl L-carnitines of general formula (I) ##STR1## wherein R is a straight or branched acyl group having 2 to 16 carbon atoms, in particular isobutyryl and isovaleryl;

Esters of acyl carnitines with long-chain aliphatic alcohols and

Amides of alkanoyl L-carnitines of general formula (1). ##STR1## wherein R is a straight or branched alkanoyl group having from 2 to 8 carbon atoms selected from acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, hexanoyl, 1-methylbutyryl, t-butylacetyl, 2-ethylbutyryl, 3-methylvaleryl, 4-methylvaleryl, 2-ethylhexanoyl and 2-propylpentanoyl;

Alkanoyl L-carnitine amides with aminoacids and pharmaceutical

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Nettuno, Italy

Mose Santaniello