Burroughs Wellcome Co.

Other

Krenitsky Pharmaceuticals, Inc.

Morton Harfenist

Charles T Joyner

Dennis Heyer

Daniel Peter McGee

Barrett R Cooper

Helen Lyng White

Eric Boros

Darryl J Heuser

Helen Lyng White, Deceased

Phenoxathin derivatives as inhibitors of monoamine oxidase

1-Ethylphenoxathiin 10,10-dioxide (I) ##STR1## inhibits monoamine oxidase-A and is useful in the treatment of disorders such as depression.

Pharmacologically active compound and use

Compounds of formula (I) ##STR1## wherein n is 0, 1 or 2;

Method for treating depression with thioxanthen-9-one derivatives

3-N-methylcarbamoylthioxanthen-9-one 10,10-dioxide of formula (I) ##STR1## is an inhibitor of monoamine oxidase-A, and is therefore useful in the prophylaxis and treatment of certain mental disorders such as depression.

Method for inhibiting monoamine oxidase-A and treating depression by

A method of inhibiting monoamine oxidase-A in a mammal such as man, comprising administration to said mammal of an effective amount of a compound of formula (I') or a physiologically acceptable salt, or a pro-drug or metabolite thereof. In formula (I') ##STR1## n is 0, 1 or 2; one of R.sup.1 and R.sup.2 is hydrogen and the other is a tetrazol-5-yl group optionally substituted by one or more C.sub.1-4 alkyl groups; and

Use of nitrogen heterocyclic compounds

This invention is directed to a carbazole compound 9-[3-(3,5-cis-dimethylpiperazino)propyl]carbazole, its salts, especially pharmaceutically acceptable salts, and solvates such as hydrates, alcoholates of the salts thereof as well as pharmaceutical compositions containing same which are useful in treating aggression and/or psychoses in humans.

Carbazole compounds and medicinal use thereof

Diphenylethers of the formula: ##STR1## their synthesis, formulations containing them, methods of making such formulations, and their use in the treatment of liver fluke infections in mammals.

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Chapel Hill, NC, United States of America

Morton Harfenist