Genta Incorporated

Trilink Biotechnologies, Inc.

Morteza M Vaghefi

David Aaron Schwartz

Mark A Reynolds

Lyle J Arnold, Jr

Richard I Hogrefe

Timothy Andrew Riley

Bob Dale Brown

The present invention provides a variety of compositions that comprise an activated carboxylic ester moiety on one end of an alkyl tether and a nucleic acid binding moiety on the other end for use as crosslinking reagents in conjugation reactions of nucleotides with solid support matrixes, organic molecules, reporter groups or other biomolecules.

Pre-activated carbonyl linkers for the modification of oligonucleotides

Oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages which hybridize to RNA target sequences and methods for their preparation are provided.

Synthetic oligomers having chirally pure phosphonate internucleosidyl

Oligomers having phosphonate internucleosidyl linkages which are enriched for phosphonate linkages of a preselected chirality which hybridize to an RNA target sequence and methods for their preparation are provided.

Chirally enriched synthetic phosphate oligomers

Methods of preparing N.sup.4 -alkanoyl, aroyl and aralkanoyl 2'-O-methylcytidine derivatives are provided. Also provided are cytidine derivatives and nucleoside monomers comprising these cytidine derivatives which are useful in the synthesis of Oligomers, including oligonucleotides and methylphosphonate Oligomers.

2'-O-methyl cytidine monomer useful in oligonucleotide synthesis

Methods of preparing N.sup.4 -alkanoyl, aroyl and aralkanoyl 2'-O-methylcytidine derivatives are provided. Also provided are novel cytidine derivatives and nucleoside monomers comprising these cytidine derivatives which are useful in the synthesis of Oligomers, including oligonucleotides and methylphosphonate Oligomers.

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San Diego, CA, United States of America

Morteza M Vaghefi