California Institute of Technology

The United States of America, as Represented by the Secretary, Department of Health and Human Services

U.S. Government Nih Division of Extramural Inventions and Technology Resources (Deitr)

Morten Sommer

Stephen R Quake

Carl L Hansen

The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth.

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Copenhagen, Denmark

Morten Sommer