H. Lundbeck A/s

Morten Jorgensen

Klaus Gjervig Jensen

Peter Hongaard Andersen

Benny Bang-Andersen

Ask Puschl

Michael Harold Rock

Andre Faldt

Michael J Mealy

Lone Munch Ringgaard

Jorgen Brodersen

Lars Kyhn Rasmussen

Thomas Ruhland

Mikkel Fog Jacobsen

Tine Bryan Stensbol

Anne Techau Bruun

Mette Graulund Hvenegaard

Lassina Badolo

Niels Mork

Jennifer Larsen

The present invention relates to deuterated 1-piperazino-3-phenyl-indanes and salts thereof with activity at dopamine receptors Dand Das well as the 5HTreceptors in the central nervous system, to medicaments comprising such compounds as active ingredients, to the use of such compounds in the treatment of diseases in the central nervous system, and to methods of treatment comprising administration of such compounds.

Deuterated 1-piperazino-3-phenyl indanes for treatment of schizophrenia

This disclosure relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulfanyl) -phenyl]piperazine or a pharmaceutically acceptable salt thereof. The process includes reacting compound II with compound III and compound IV in the presence of a solvent, a base and a palladium catalyst. R, R', X, and Xin the formulas above are defined in the Specification.

Process for preparing 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine or pharmaceutically acceptable salt thereof

This disclosure relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine or a salt thereof. The process includes reacting compound II with compound III and compound IV in the presence of a solvent, a base and a palladium catalyst. R, R', X, and Xin the formulas above are defined in the Specification.

Process for preparing 1-[2-(2,4-dimethylphenysulfanyl)-pheny]piperazine or pharmaceutically acceptable salt thereof

The present invention is directed to pyridine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psychiatric disorders. 

Substituted 2,3,5,9,9B-pentaazacyclopenta[a]naphthalenes and uses thereof

Deuterated 1-piperazino-3-phenyl-indanes for treatment of schizophrenia

The present invention relates to novel catecholamine derivatives of Formula I, to processes for their preparation, pharmaceutical compositions containing them and to their use in therapy.

Catecholamine derivatives and prodrugs thereof

The present invention relates to novel phenolic and catecholic amines of Formula I, to processes for their preparation, pharmaceutical compositions containing them, to their use in therapy and to their use in radiolabeled form as PET- or SPECT ligands.

Phenolic and catecholic amines and prodrugs thereof

The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder. 

4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors

Growing community of inventors

Bagsvaerd, Denmark

Morten Jorgensen