Joslin Diabetes Center, Inc.

Housey, Gerard M.

White, Morris F.

Morris F White

Gerard M Housey

C Ronald Kahn

Paul L Rothenberg

Jacalyn H Pierce

Xiao Jian Sun

A substantially pure nucleic acid comprising a sequence encoding an IRS-2 polypeptide, a substantially pure preparation of an IRS-2 polypeptide, and related methods.

DNA encoding an insulin receptor substrate

A substantially pure nucleic acid comprising a sequence encoding a pp60.sup.PIK peptide and methods of using nucleic acid encoding pp60.sup.PIK to make pp60.sup.PIK polypeptide.

Nucleic acid encoding pp60.sup.PIK and the methods of making

A purified protein that is identified herein as insulin receptor substrate 1 (IRS-1) is disclosed, as well as a method of purifying IRS-1 and a recombinant nucleic acid encoding it.

Insulin receptor substrate

A purified nucleic acid consisting essentially of nucleic acid encoding insulin receptor substrate 1.

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West Roxbury, MA, United States of America

Morris F White