Kyowa Hakko Kogyo Co., Ltd.

Abbott Laboratories Corporation

Kyowa Hakko Bio Co., Ltd.

Moriyuki Sato

Seiga Itoh

Kazuo Yamaguchi

Motoo Yamasaki

Makoto Morimoto

Yoshiharu Yokoo

Yasuki Mori

Masami Okabe

Hiromasa Miyaji

Tetsuro Kuga

Yoshinori Komatsu

Hajime Yoshida

Tatsunari Nishi

Akiko Saito

Susumu Sekine

Shinkichi Honda

Kenichi Mochida

Shigeo Yoshiie

Takashi Nara

Tamio Mizukami

Ryo Okachi

Mitsuyoshi Yamamoto

Masahiro Sugimoto

Yoshiaki Shimizu

Ryoichi Katsumata

Kunikatsu Shirahata

Katsutoshi Sasaki

Toru Mizukami

Tetsuya Hirano

Shigenori Ohta

Hiroshi Kawauchi

Shigeyoshi Yasumura

Kei Okazaki

Yasutoshi Takeichi

Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.

G-CSF conjugate

A novel motilin analog peptide containing leucine instead of the usual 13th amino acid methionine, as in the naturally occurring motilin, is produced by gene recombination techniques in which several or identical genes, each coding for the novel peptide, are joined in series into a vector. The resultant recombinant DNA is introduced into Escherichia coli and the resultant transformant is cultivated. The resulting polymeric peptide can be cleaved to give the desired peptide.

DNA coding for (Leu.sup.13) motilin

Method of producing a polypeptide having human granulocyte colony

Polypeptide derivatives of human granulocyte colony stimulating factor

DNAs coding for �LCU.sup.13 ! motilin

Method for producing �Leu.sup.13 !motilin

DNA encoding human granulocyte colony stimulating factor plasmids and

[Leu13]motilin, DNAs coding for same and methods for producing same

A polypeptide or glycosylated polypeptide with at least one new carbohydrate chain produced by means of recombinant DNA technique, which has protease resistance and thermal stability and is expected to have longer lifetime in blood than those of a naturally-occurring form.

Modified granulocyte-colony stimulating factor polypeptide with added

The present invention provides a recombinant DNA comprised of a vector DNA and a DNA fragment containing a gene coding for .gamma.-glutamyl transpeptidase derived from Bacillus subtilis. The invention also provides a process for producing .gamma.-glutamyl transpeptidase, which comprises culturing in a culture medium a microorganism belonging to the genus Bacillus which is carrying recombinant DNA comprised of a vector DNA and DNA fragment which contains a gene coding for .gamma.-glutamyl transpeptidase derived from the genus Bacillus, accumulating .gamma.-glutamyl transpeptidase in the culture, and recovering .gamma.-glutamyl transpeptidase therefrom.

Process for the production of .gamma.-glutamyl transpeptidase

Disclosed is a novel derivative of human IFN-.gamma. polypeptide wherein certain amino acids of human IFN-.gamma. polypeptide are removed and certain amino acids other than said amino acids are replaced with other amino acids. The derivatives have high IFN-.gamma. activity and are expected to be useful as drugs such as anti-viral and anti-tumor agents.

Novel human interferon-.gamma. polypeptide derivative

Disclosed are peptides which have amino acid sequences consisting of 15 to 26 amino acid constituents and have phospholipase A.sub.2 -inhibiting activity.

Phospholipase A.sub.2 -inhibiting peptides

Growing community of inventors

Tokyo, Japan

Moriyuki Sato