Monsanto Technology LLC

Prolexys Pharmaceuticals, Inc.

Moritz Von Rechenberg

James Arthur Baum

Artem G Evdokimov

Farhad Moshiri

Andrew M Wollacott

Timothy J Rydel

Meiying Zheng

Eric J Sturman

Halong Vu

Stanislaw Flasinski

Paul B Robbins

John M Peltier

Brent R Stockwell

John Jay Boniface

Longwu Qi

Robert Selliah

Raj Gopal Venkat

Sudhir R Sahasrabudhe

Justin Savage

Robert R Becklin

Cindy Lou Chepanoske

Keith Simmon

Eugene Y Zhen

Vladimir Kery

The present invention discloses Hemipteran insect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.

Proteins toxic to Hemipteran insect species

Proteins toxic to hemipteran insect species

The present invent in disclosesinsect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.

The present invention disclosesinsect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.

The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.

Quinoxaline derivatives as antitumor agents

The present invention provides a method for purifying a protein complex and the components comprising the complex from a cell, a cell or tissue lysate or a whole organism by employing a combined set of affinity tags of high affinity, specificity and ease of elution. The method involves using a protein or a peptide modified to contain one or more affinity tags separated by one or more specific protease cleavage sites to isolate any interacting proteins or fragments thereof. Specifically exemplified is a method employing a modified bait containing AviTag or GST and a removal tag of Hishexapeptide positioned proximal to the bait such that any excess bait can be efficiently removed from the purified complex yielding enriched interacting proteins prior to subjecting the complex for further identification of individual components. The identification of the proteins or fragments thereof contained in the protein complex will provide new targets for the identification of new pharmaceuticals and diagnostic tools.

Method for purification of a protein complex and identification of its components

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Waltham, MA, United States of America

Moritz Von Rechenberg