Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt

Moritz Gegg

Heiko Lickert

Adriana Migliorini

Erik Bader

The present invention relates to the use of the biomarker Flattop (Fltp) for distinguishing mature &#x3b2; cells from immature progenitor &#x3b2; cells. The present invention further relates to a method for distinguishing a mature &#x3b2; cell from an immature progenitor &#x3b2; cell, the method comprising: determining the presence or absence of the biomarker Flattop (Fltp) in a &#x3b2; cell; wherein the presence of Fltp in the cell indicates that the cell is a mature &#x3b2; cell and wherein the absence of Fltp in the cell indicates that the cell is an immature progenitor &#x3b2; cell. Furthermore, the present invention relates to a method of identifying a compound suitable for differentiating immature progenitor &#x3b2; cells into mature &#x3b2; cells as well as to a method of identifying a compound suitable for preventing the de-differentiating of mature &#x3b2; cells. The present invention additionally relates to a method of differentiating immature progenitor &#x3b2; cells into mature &#x3b2; cells as well as to a method of preventing de-differentiating of mature &#x3b2; cells. In addition, the present invention also relates to a kit for distinguishing mature &#x3b2; cells from immature progenitor &#x3b2; cells and to a pharmaceutical composition for use in treating or preventing diabetes.

Flattop (fltp) is a novel biomarker for beta cell maturation

The present invention relates to the use of the biomarker Flattop (Fltp) for distinguishing mature &#x3b2; cells from immature progenitor &#x3b2; cells. The present invention further relates to a method for distinguishing a mature &#x3b2; cell from an immature progenitor &#x3b2; cell, the method comprising: determining the presence or absence of the biomarker Flattop (Fltp) in a &#x3b2; cell; wherein the presence of Fltp in the cell indicates that the cell is a mature &#x3b2; cell and wherein the absence of Fltp in the cell indicates that the cell is an immature progenitor &#x3b2; cell. Furthermore, the present invention relates to a method of identifying a compound suitable for differentiating immature progenitor &#x3b2; cells into mature &#x3b2; cells as well as to a method of identifying a compound suitable for preventing the de-differentiating of mature &#x3b2; cells.

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Munich, Germany

Moritz Gegg