Bayer Aktiengesellschaft

Bayer Pharma Aktiengesellschaft

Moritz Beck-Broichsitter

Udo Albus

Klemens Lustig

Michael Hahn

Martina Delbeck

Doris Gehring

Björn Rosenstein

Karl Collins

Janine Nicolai

Thomas Ernst Müller

Niels Lindner

Johanna Anlahr

Thomas Müller

Hongkai Dang

Dehe Duan

Jianfei Yang

Denghui Chen

The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, such as compounds of the general formula (I): to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders

The present application relates to novel imidazopyridinyl- or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives of formula (I), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring. Formula (I) in which the ring Q represents a bridged 1,4-diazepane cycle. 

Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors

The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

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Darmstadt, Germany

Moritz Beck-Broichsitter