Sanwa Kagaku Kenkyusho Co., Ltd.

Ube Industries, Inc.

Morio Okabe

Daisuke Kurumazuka

Toru Izuchi

Satoko Harada

Toshiyuki Miyazawa

Tomio Kimura

Motohisa Shimizu

Yasunori Tsuzaki

Hiroki Nagano

Ryo Iwamura

Hiroyuki Setoguchi

Mitsuaki Takeuchi

Kaori Taniko

Yuka Kuno

Hiroto Akaza

Katsunori Kitamoto

Yurie Yamada

Yukiyasu Asano

Izumi Gotoh

Naoki Takahashi

Keita Sakai

Hiroki Fujieda

Yasushi Ohsawa

Hiroyo Kataoka

Nobuyoshi Kasugai

Yuuki Imura

Tatsuroh Kaneko

The object of the present invention is to provide a compound having an antagonistic action against &#x3bc;-opioid receptors, which causes less side effects and thus is highly safe. A compound represented by the general formula (I), or a pharmacologically acceptable salt thereof:   

3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose

A compound having a V2 receptor agonistic activity is provided. Providing a pharmaceutical composition which contains, as an active ingredient, a compound represented by general formula (I) described below: [Ris formula described below: (A is a lower alkylene group which may be substituted with lower alkyl group; Ris a hydrogen atom; Ris a hydroxyl group, an aromatic heterocyclic group which may be substituted with lower alkyl group, carbamoyl group); Ris a hydrogen atom or lower alkyl group; Ris lower alkyl group which may be substituted with 1-3 fluorine atoms, or halogen atom; Ris a five-membered aromatic monocyclic heterocyclic group, five-membered non-aromatic monocyclic heterocyclic group, (provided each heterocyclic groups contain at least one nitrogen atom and may be substituted with a lower alkyl group); and Ris a lower alkyl group, halogen atom], or pharmacologically acceptable salt thereof.

Benzoazepine derivative and medical use thereof

Growing community of inventors

Kariya, Japan

Morio Okabe