Gilead Sciences, Inc.

Morin Mae Frick

William John Watkins

Kevin S Currie

Dustin S Siegel

Peter A Blomgren

Jeffrey E Kropf

Xianghong Wang

Joshua A Kaplan

Edward Doerffler

Robert William Scott

Bruce Ross

Willard Lew

Lars V Heumann

Silvio A Campagna

Katrien Brak

Andrew W Waltman

Andrew C Stevens

Tiago Vieira

Robert Ronald Milburn

Sean Timothy Neville

Pavel Robertovich Badalov

Andrei Chtchemelinine

Detian Gao

Mark Charles Whitcomb

Elizabeth M Horstman

Chia-Yun Yu

Lydia Wolfe

Clarissa Tadeus

Erik Rueden

Brittanie Hoang

Silvio Campagna

Steven Donald Axt

Tiago Viera

Erick Rueden

Dustin Siegel

Provided are methods of preparing compounds and pharmaceutical compositions comprising a compound Formula VIII for treating Filoviridae virus infections. In one aspect, the compound of Formula VIII is formed from a reaction mixture comprising the compound of Formula IX, the compound of Formula X, a coupling agent such as magnesium chloride and a non-nucleophilic base such as diisopropylethylamine. The compound of Formula IX can be formed from a compound of Formula V and a cyanating agent. The compound of Formula V can be synthesized from a reaction mixture comprising a deprotonating agent such as phenylmagnesium chloride; a silylating agent such as chlorotrimethylsilane; a coupling agent such as isopropylmagnesium chloride, an additive such as LaCl-2LiCl, LaCl, CeCl, NdCl, or YCl; a compound of Formula VI; and 7-iodopyrrolo[2,1-f][1,2,4]triazin-4-amine. The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Methods for the preparation of ribosides

The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

FXR (NR1H4) modulating compounds

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San Mateo, CA, United States of America

Morin Mae Frick