Asahi Kasei Medical Co., Ltd.

Asahi Medical Co., Ltd.

Morikazu Miura

Tomohisa Yokomizo

Tatsuya Fukuda

Teruhiko Oishi

Hiromi Nirasawa

Hirofumi Miura

This invention relates to a blood processing filter comprising a sheet-like filter element, an inlet-side flexible container and an outlet-side flexible container that sandwich the filter element and are sealed thereto, an inlet port provided in the inlet-side flexible container for accepting blood before being processed by the filter element, and an outlet port provided in the outlet-side flexible container for discharging blood after being processed by the filter element. The blood processing filter also includes a flow channel securing sheet arranged between the filter element and the outlet-side flexible container. A flow channel hole through which blood processed by the filter element passes is formed in the flow channel securing sheet. The outlet port is provided so as to be capable of communicating with the flow channel hole.

Blood processing filter and the method for manufacturing the same

A blood processing filter including a flexible container (having an inlet and an outlet and a sheet-like filter member that is assembled in the flexible container) has a seal part that seals the flexible container and the filter member to form an effective filtration portion of the filter member and a partition part that seals the flexible container and the filter member to partition the effective filtration portion into a plurality of areas. The seal part and the partition part cooperate with the filter member to divide inside of the flexible container into three or more internal spaces including an inlet space that communicates with the inlet, and an outlet space that communicates with the outlet, and also form, as a blood channel, a channel that passes through each of three or more of the internal spaces and also passes multiple times through the filter member.

Blood processing filter

This invention relates to a blood processing filter including a band-shaped first seal part that seals an inlet-side flexible container of the blood processing filter and a filter element of the blood processing filter so as to surround an inlet port, and an annular second seal part that seals at least the inlet-side flexible container and an outlet-side flexible container and is formed surrounding the first seal part at a position that is closer to an outer edge than the first seal part. A valley part corresponding to the first seal part is provided on an outlet side of the filter element. An outlet opening that communicates with an inside of the outlet-side flexible container is formed in the outlet port. At least one portion of the outlet opening is arranged so as to overlap with the valley part.

Provided are a method of conveniently and efficiently removing abnormal prion protein from a blood product and a method of removing leukocyte simultaneously with abnormal prion protein. The method of removing an abnormal prion protein from a blood product includes filtering the blood product through a filter filled with a carrier coated with a polymer, which is composed of three units including 20 mol % or more and 40 mol % or less of a unit originating from a hydrophobic polymerizable monomer, 5 mol % or more and 13 mol % or less of a unit originating from a polymerizable monomer containing a basic nitrogen-containing part, and a unit originating from a polymerizable monomer containing a protonic neutral hydrophilic part as the balance, and then recovering the filtered blood product.

Method of removing abnormal prion protein from plasma or erythrocyte product

This invention relates to a blood processing filter including a sheet-like filter element and a flexible container having an internal space divided by the filter element. The container includes first and second container-forming-parts. The first container-forming-part includes an interior filtration space-forming-part and an exterior surrounding space-forming-part that are separated by a first seal-part. The second container-forming-part includes an extension space-forming-part surrounded by the second seal-part and arranged opposite the filter element and the surrounding space-forming-part, without being divided by the first seal-part. A port of the first container-forming-part is provided in the filtration space-forming-part and communicates with an internal space on one side defined by the filter element. The port of the second container-forming-part is provided in the extension space-forming-part and communicates with an internal space on another side defined by the filter element, and protrudes further than an outer surface of the extension space-forming-part.

Blood processing filter and method for priming the filter

Methods wherein a blood cell concentration gradient is formed in a pooling unit in which blood is pooled before or after introducing the blood into a filter for eliminating leukocytes followed by the filtration are disclosed. By the first method comprising forming a blood cell concentration gradient in the pooling unit before introducing blood into the filter for eliminating leukocytes followed by the filtration, leukocytes can be efficiently eliminated from a whole blood preparation or a high platelet collection ratio can be established while maintaining a high leukocyte elimination ratio. By the second method comprising forming a blood cell concentration gradient in the pooling unit after introducing blood into the filter for eliminating leukocytes followed by the filtration, leukocytes can be efficiently eliminated from a whole blood preparation or a platelet preparation and platelets can be collected at a high ratio.

Blood filtration methods

A filter for reducing leukocytes and platelets from an erythrocyte preparation or a whole blood preparation which is characterized by having a filter base coated with a polymer, the content of the polymer being from 0.5 to 10 mg/mper unit area of the total surface of the filter base, and the polymer containing 20% or less of low-molecular weight components having a molecular weight not more than &#xbc; of the peak top molecular weight in the gel permeation chromatogram.

Filter for processing blood and process for producing the same

A filter for selectively removing leukocytes from the human whole blood, characterized in that it comprises a filter base coated with a hydrophilic synthetic polymer having a weight-average molecular weight of 300,000 to 3,000,000 and that the percentage of covering by the polymer is 70% or higher based on the whole surface of the filter base.

Growing community of inventors

Tokyo, Japan

Morikazu Miura