The Johns Hopkins University

Morgana M Trexler

Marcia W Patchan

Jennifer H Elisseeff

Jeffrey P Maranchi

Julia B Patrone

Xiomara Calderon-Colon

Jennifer L Breidenich

Jenna L Graham

George L Coles

Jason J Benkoski

Steven M Storck

Chao-Wei Hwang

Hala J Tomey

Robert C Matteson, Iii

John M Brupbacher

Zhiyong Xia

Christopher M Hoffman, Jr

Jennifer L Sample

Dajie Zhang

Matthew Yeager

Christopher M Peitsch

Qiongyu Guo

Andrew M Lennon

Lisa A Kelly

Ian D McCue

Jon R Resar

Daniel Mulreany

Douglas A Smith

Andrew C Merkle

Jeffrey M Paulson

Salahudin M Nimer

Catherine M Carneal

Matthew G Bevan

Vanessa D Alphonse

Jon R Rosar

Salahudin N Nimer

Quang T Luong

Mark A Athey

Kathleen M Perrino

Oliver D Schein

Additive manufacturing processes, systems and three-dimensional articles include the formation of voxels and/or portions of three-dimensional articles with different properties relative to other voxels and/or portions. The processes generally include changing one or more laser beam parameters including power level, exposure time, hatch spacing, point distance, velocity, and energy density during the formation of selected voxels and/or portions of the three-dimensional articles. Also disclosed are processes that include an additive manufacturing process that provides localized secondary heat treatment of certain voxels and/or regions at a temperature below the melting point of the three-dimensional article but high enough to effect a localized property change.

Localized tailoring of three-dimensional articles via additive manufacturing

A nanofiber comprising a polyamide including at least one substituted phenyl group is provided. The nanofiber includes an average diameter from about 50 to about 1000 nm. A fibrous mat including a plurality of the nanofibers is also provided. A composite including a plurality of the nanofibers and a continuous matrix resin is also provided. A method of forming the nanofibers is also provided.

Electrospun nanofibers

A system provided herein may be configured to evaluate helmet performance. The system may include an impact assembly that includes a stationary post operably coupled to one or more stationary load cells and a plurality of modular headforms. Each modular headform may include a first side and a second side configured to lock together around the impact assembly and receive a helmet. The modular headform may determine a position of the helmet relative to the one or more stationary load cells. Furthermore, the one or more stationary load cells may be configured to measure impact force at a position where one of the plurality of the modular headforms are operably coupled to the impact assembly. Additionally, each of the plurality of modular headforms correspond to a position in relation to the impact assembly to measure the impact force to the one or more load cells at a predefined number of impact locations on the helmet to evaluate the performance of the helmet.

System and method for evaluation of helmet performance

Example methods and articles of manufacture related to electrospun aramid nanofibers are provided. One example method may include forming a resultant solution by reacting a solution of aramids dissolved in a solvent with an electrophile. In this regard, the electrophile may perform a side chain substitution on the dissolved aramids. The example method may further include electrospinning the resultant solution to form an aramid nanofiber.

Electrospinning aramid nanofibers

Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.

Method of manufacturing an implantable pressure-actuated drug delivery system

Methods of manufacture and use of implantable pressure-actuated drug delivery systems

The present invention provides cellulose hydrogels having one or more of the following properties: high water content, high transparency, high oxygen permeability, high biocompatibility, high tensile strength and desirable thermal stability. The present invention further provides a process for preparing a cellulose hydrogel comprising (i) a step of activating cellulose, in which the activating step comprises contacting the cellulose with a solvent to activate the cellulose for a time duration from about 2 hours to about 30 hours; (ii) substantially dissolving the activated cellulose to form a solution; and (iii) gelling the solution to form a gel, in which the gelling step comprises allowing the solution to gel in an environment comprising a relative humidity from about 30% to about 80% at 35&#xb0; C.

Cellulose hydrogel compositions and contact lenses for corneal applications

The present invention provides a wound healing composition comprising a biocompatible hydrogel membrane wherein the hydrogel membrane has one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The invention further provides methods of treating a wound in a subject in need thereof, comprising contacting the wound with a biocompatible cellulose hydrogel membrane of the invention.

Wound healing compositions comprising biocompatible cellulose hydrogel membranes and methods of use thereof

A method includes producing an article having a substrate with a plurality of independent taggant layers that each include metal oxide nanocrystals doped with at least one Lanthanide element. Each taggant layer includes metal oxide nanocrystals doped with a different Lanthanide element than each other taggant layer.

Method of producing nanoparticle taggants for explosive precursors

An article includes a substrate with a plurality of independent taggant layers that each include metal oxide nanocrystals doped with at least one Lanthanide element. Each taggant layer includes metal oxide nanocrystals doped with a different Lanthanide element than each other taggant layer.

Nanoparticle taggants for explosive precursors

The present invention provides cellulose hydrogels having one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The present invention further provides a process for preparing a cellulose hydrogel comprising: (i) contacting cellulose with a solvent to activate the cellulose; (ii) optionally removing the solvent from the activated cellulose; (iii) substantially dissolving the activated cellulose to form a solution; (iv) allowing the solution to gel; and optionally (v) drying the gel and rehydrating the gel. The cellulose hydrogel can have many uses, including uses as contact lenses.

Cellulose-based hydrogels and methods of making thereof

Implantable pressure-actuated drug delivery systems and methods of manufacture and use

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Baltimore, MD, United States of America

Morgana M Trexler