Eisai R&d Management Co., Ltd.

Morgan Welzel O'shea

John JianShi Wang

Guo Zhu Zheng

Ming-Hong Hao

Atsushi Endo

Dominic J Reynolds

Yoshihiko Kotake

Gregg F Keaney

Andrew Cook

Kazunobu Kira

Parcharee Tivitmahaisoon

Sudeep Prajapati

Norio Murai

Jason T Lowe

Baudouin Gerard

Xiang Liu

James Palacino

Shelby Ellery

Satoshi Nagao

Masayuki Miyano

Kenzo Arai

Regina Mikie Kanada Sonobe

Nicholas C Gearhart

Lisa A Marcaurelle

Tuoping Luo

The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Certain pladienolide compounds and methods of use

Growing community of inventors

Arlington, MA, United States of America

Morgan Welzel O'shea