University of Pittsburgh

Morgan V Fedorchak

Steven R Little

Joel Steven Schuman

Andrew Jason Glowacki

Jenny Yu

Michelle L Guaragno

Michael A Washington

Stephen C Balmert

Anthony Cugini

Leah C Byrne

Joel S Schuman

José-Alain Sahel

Disclosed herein are embodiments of a polymer-based implant and methods of making and using the same. The polymer-based implant comprises a polymer component and a therapeutic agent. In some embodiments, the polymer-based implant can be used to treat and/or prevent retinal diseases and/or retinopathies. The polymer-based implant exhibits physical properties that provide the ability to safely place the polymer-based implant in an ocular region without undesired diffusion and also to allow for controlled and timely release of the therapeutic agent to a desired region of the ocular region, such as the retina. In particular disclosed embodiments, the polymer-based implant can be used for safe and effective gene therapy.

Polymer-based implant for retinal therapy and methods of making and using the same

A method for sustained delivery of an agent to an ocular organ in a subject, comprising topically delivering to the ocular surface a liquid thermoresponsive hydrogel comprising agent-loaded polymer microparticles, wherein the agent is sustainably released for a period of at least five days.

Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular drug delivery

A method comprising treating a periocular wound in a subject, comprising topically administering to the periocular wound a composition comprising at least one thermoresponsive gel.

Gel for treating periocular and/or orbital pathologies and conditions

A method for treating an ocular disorder in a subject comprising administering a therapeutic agent-loaded carrier to an ocular site of the subject in need thereof, wherein the therapeutic agent loaded-carrier provides controlled delivery of the therapeutic agent under conditions suitable for recruiting regulatory T cells to an ocular region of interest or inducing regulatory T cells in an ocular region of interest.

Biomimetic drug delivery of an immunomodulatory agent for the treatment of ocular conditions

Methods for treating an ear condition in a subject, comprising topically administering to the ear of the subject in need thereof a composition comprising: (i) an anti-infective agent-loaded biodegradable polymer microspheres; and (ii) a thermoresponsive hydrogel.

Growing community of inventors

Mars, PA, United States of America

Morgan V Fedorchak