Board of Regents of the University of Nebraska

Moorthy P Ponnusamy

Surinder K Batra

Maneesh Jain

Novel antibodies for the detection and/or treatment of a cancer (e.g., a pancreatic cancer or an ovarian cancer) are provided. In certain embodiments the antibodies bind a region of the MUC4 protein that does not comprise the central tandem repeat (TR) domain of MUC4. Certain antibodies bind to the MUC4 peptide fragment MUC4-&#x3b1;-N-Ter and/or to the MUC4 peptide fragment MUC4-&#x3b1;-C-Ter. Chimeric constructs comprising such antibodies are also provided.

Compositions and methods for detection and treatment of cancer

Compositions and methods for treating, detecting, and diagnosing cancer are disclosed.

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Omaha, NE, United States of America

Moorthy P Ponnusamy