Korea Research Institute of Chemical Technology

Rexahn Pharmaceuticals, Inc.

Sk Chemicals Co., Ltd.

Rexhan Pharmaceuticals, Inc.

Moon-Kook Jeon

Young-Dae Gong

Jae Yang Kong

Young Bok Lee

Soon-Hee Hwang

Gun-Do Kim

Dong-Su Kim

Sung-Eun Yoo

Eun Ju Lee

Chang Ho Ahn

Jong Yeon Hwang

Wie-Jong Kwak

Nam Kyu Lee

Gildon Choi

Heeyeong Cho

Dae Young Jeong

Chang-Ho Ahn

Yong-Baik Cho

Sukho Lee

Taeho Lee

Hyae-Gyeong Cheon

Jin-Soo Seo

Jeong-Ran Kim

Mi-Sook Dong

Cho Young Sik

Choi Hyung Sub

Jeon Hyun Suk

Song Jin Sook

Kim Chi Hyun

Jung Bum Lee

Jun Won Lee

The present invention relates to novel quioxaline-piperazine compounds, 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives of formula (1): and their pharmaceutically acceptable salts, a process for their preparation thereof, and compositions containing such compounds. Therapeutic methods for the treatment of hyperproliferative disorders, including cancers, by administering quioxalin-piperazine compounds are also included.

1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives for treating tumors

The present invention related to a novel urea derivative for formula (I): which is useful as an anti-cancer agent, its pharmaceutically acceptable acid addition salt or stereoisomer, and to a process for preparing the urea derivative and an anti-cancer composition comprising the same as an active ingredient.

1-[6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives

The present invention relates to a novel benzopyran derivative having goodantagonistic activity on TGF-&#x3b2; receptor which can be effectively used as a prophylactic and therapeutic agent for liver disease as well as several fibroplasiadiseases such as hepatic fibrosis, liver cirrhosis, pulmonary fibrosis, dermatosclerosis, glomerular fibrosis and the like; and a pharmaceutical use thereof.

Benzopyran derivatives having inhibitory activities against liver fibrosis and cirrhosis and their pharmaceutical uses

Disclosed herein are 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives, a preparation method thereof, and a therapeutic agent for treating inflammatory diseases induced by SPC, which contains the derivative as an active ingredient. The anti-inflammatory effect of the 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives was analyzed through a test employing human dermal cells and an animal test using mice and, as a result, it was found that the derivatives showed excellent inhibitory activity on SPC receptor compared to thiazole derivatives known in the prior art. Thus, the 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives or pharmaceutically acceptable salts thereof are useful as active ingredients in therapeutic agents for treating inflammatory diseases, such as inflammation, pruritus and skin infection, which appear in atopic dermatitis and other diseases induced by SPC activity. wherein R, R, Rand Rare as defined in the specification.

2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives for therapeutic agent of antiinflammatory disease, method thereof for preparation, therapeutic agent for antiinflammatory disease induced by SPC activity containing the same

The present invention relates to a noble 6-alkylamino-2-methyl-2'-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative, a method for preparing the same with high efficiency using a parallel synthetic method, one of combinatorial chemical synthetic techniques, and a use of the novel compound showing a high inhibitory effect to 5-lipoxygenase (5-LO) activity for preventing and treating leukotriene (LTA4, B4, C4, D4) activation-related diseases such as inflammatory diseases, rheumatoid arthritis, colitis, asthma and psoriasis.

6-Alkylamino-2-methyl-2'-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative as anti-inflammatory inhibitor

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Daejeon, South Korea

Moon-Kook Jeon