Hanmi Pharm. Co., Ltd.

Hanmi Science Co., Ltd.

Moon-Hyuk Chi

Yong-Il Kim

Jong Soo Woo

Jong-Soo Woo

Jae-Kuk Ryu

Si-Young Jung

Hong-Gi Yi

The sustained release formulation for oral administration of an HMG-CoA reductase inhibitor of the present invention can be easily and economically prepared and is capable of maintaining a constant drug level in blood by slowly releasing the HMG-CoA reductase inhibitor at a uniform rate for 24 hrs. Accordingly, the sustained release formulation of the present invention can be effectively used for lowering blood cholesterol and triglyceride levels.

Sustained release formulation for oral administration of HMG-CoA reductase inhibitor and method for the preparation thereof

A sustained-release composition for oral administration of a drug, comprising the drug, a mixture of sodium alginate and xanthan gum as a carrier for sustained release and a mixture of hydroxypropyl methylcellulose and propylene glycol alginate as a gel hydration accelerator, which is capable of maintaining a constant drug level in blood for 24 hours or more. Due to rapid gel hydration without forming a non-gelated core, the drug release rate follows zero order kinetics and does not significantly vary with the degree of gastrointestinal motility.

Sustained release composition for oral administration of drugs

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Suwon-si, South Korea

Moon-Hyuk Chi