Korea Institute of Science and Technology

Moon Ho Chang

Ae Nim Pae

Yong Seo Cho

Hun Yeong Koh

Hyun Jung Kang

The present invention relates to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by the following Chemical Formula 1, from trimethylsilanylmethyl-allenol derivative by the intramolecular Prins cyclization using Lewis acid. The 7-membered carbocyclic compound is a useful intermediate for synthesis of other multicyclic compounds.  In Chemical Formula 1, Ris a Cto Calkyl group, and Rand Ris respectively a hydrogen atom, or R, Rand Rmay be connected with neighboring substituents to form a 5 to 10-membered aliphatic or aromatic ring.

Synthesis of 7-membered carbocyclic compound having diexomethylene groups

The present invention relates to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by the following Chemical Formula 1, from trimethylsilanylmethyl-allenol derivative by the intramolecular Prins cyclization using Lewis acid. The 8-membered carbocyclic compound is a useful intermediate for synthesis of other multicarbocyclic compounds. In Chemical Formula 1, Ris a phenyl group, and Rand Ris a hydrogen atom, or R, Rand Rmay be connected with neighboring substituents to form a 5 to 10-membered aliphatic or aromatic ring.

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Seoul, South Korea

Moon Ho Chang