Esteve Quimica S.a.

Montserrat Monsalvatje Llagostera

Salvador Puig Torres

Yolanda Gasanz Guillén

Marti Bartra Sanmarti

Martí Bartra Sanmartí

Pedro Talavera Escasany

Jaime Tomas Navarro

Laura Coppi

It comprises a process for the purification of Montelukast, or its salts or its solvates, including any stereoisomer or mixture thereof, which comprises converting Montelukast acid or a solvate thereof, including any stereoisomer or mixtures thereof, into an amine salt selected from the group consisting of tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3-propanediol, and L-(+)-&#x3b1;-phenylglycinol salt, in the presence of an appropriate solvent. It also comprises novel salts of Montelukast, in particular, tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3-propanediol, and L-(+)-&#x3b1;-phenylglycinol salts.

Purification process of Montelukast and its amine salts

The process for obtaining quinapril hydrochloride (I) comprises the stages of: a) hydrogenolysis of the benzyl ester of quinapril (II) by treatment in an alcoholic solvent, with concentrated hydrochloric acid or a solution of hydrogen chloride in isopropanol, and hydrogenation; b) removal of the solvent; c) addition of toluene to precipitate the quinapril hydrochloride as a toluene solvate; d) treatment of said solvate with a Class 3 solvent which forms a solvate of quinapril hydrochloride from which it can be removed by drying without degrading; and e) drying of the solvate from step d) to yield quinapril hydrochloride (I), an antihypertensive agent.

Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride

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Montserrat Monsalvatje Llagostera