Grifols, S.a.

Laboratorios Ojer Pharma, S.l.

Montserrat Miñarro Carmona

Salvador Grancha Gamon

Josep Maria Suñé Negre

Carlos González Ojer

Anna Nardi Ricart

Pilar Pérez Lozano

Josep Ramón Tico Grau

Encarna García Montoya

Josep Mariá Suñe Negre

Raquel Maria Da Costa Martins

Josep Ramon Ticó Grau

Manel Roig Carreras

Natalia Sánchez Porqueres

Josep M Suñé Negre

The present invention provides a gel combination comprising: polycarbophil in an amount comprised from 1 to 5% by weight; polyvinylpirrolidone in an amount comprised from 4 to 8% by weight; glycerine in an amount comprised from 1 to 10% by weight; and propyleneglycolin an amount comprised from 20 to 40% by weight; wherein: the weight ratio between polyvinylpirrolidone:polycarbophil is comprised between 1:1 and 4:1, the weight ratio between glycerine:polycarbophil is comprised from 0.5:1 to 2:1, and the weight ratio propyleneglycol:polycarbophil is comprised from 8:1 to 20:1. The invention also provides transparent compositions comprising such gel combinations as well as processes for their preparation and the use thereof as a medicament. Due to the specific excipients, % by weight, and weight ratios forming the combination, the resulting compositions show a high bioadhesivity and bioavailability of the active ingredient, without toxic adverse effects.

Gel compositions

Composition of biocompatible microparticles of alginic acid for the controlled release of active ingredients by intravenous administration. The invention relates to a biocompatible composition which comprises microparticles of alginic acid or its salts and an active ingredient. More particularly, the invention relates to microparticles for the encapsulation of an active ingredient to be administered intravenously to a patient who needs it. These microparticles are of a combination of size sufficient to increase the half-life or survival of the active ingredient in blood, with a low uptake in the liver and a fast cell clearance when administered intravenously.

Composition of biocompatible microparticles of alginic acid for the controlled release of active ingredients by intravenous administration

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Barcelona, Spain

Montserrat Miñarro Carmona