Centre National De La Recherche Scientifique

Université De Nantes

Institut National De La Sante Et De La Recherche Medicale

Université Du Mans

Chu Nantes

Monique Mathé

Jacques Lebreton

Dominique Heymann

Maxim Egorov

Yannick Fortun

Marc Padrines

Francoise Redini

Fabrice Fleury

Alexandre Demeyer

Pierre Weigel

Benoit Chenais

Françoise Redini

Compounds of general formula: wherein Rand Rare independently selected from hydrogen and pharmaceutically acceptable cations; and Rand Rare identical and selected from amide, carbamate, sulphonamide, azido, cyano and halide. Also, a pharmaceutical composition including one of the compounds. The composition may also include another active ingredient, especially an antineoplastic agent. Further a compound or a composition for use as a medicament, especially a compound or a composition for use in the treatment of a proliferative disease such as for example cancer.

Disulfonate stilbenes for use in the treatment of proliferative diseases

The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: -n and m denote, independently of one another, an integer ranging from 1 to 4, &#x2014;X denotes an oxygen atom or an N&#x2014;R3 group, &#x2014;R1 and R3 denote, independently of one another, a linear or branched Cto Calkyl group, and &#x2014;R2 denotes a residue of a molecule of therapeutic or diagnostic interest, or pharmaceutically acceptable salts of said derivatives, and also the method for the preparation thereof and the therapeutic or diagnostic use thereof. 

Hydroxy-bisphosphonic acid derivatives as vector targeting bone tissue

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Nantes, France

Monique Mathé