Immatics Us, Inc.

Monique Dao

Norbert Hilf

Sabrina Kuttruff-Coqui

Melinda Mata

Yannick Bulliard

Sarah Missell

Steffen Walter

Aleksandra Nowicka

Aleksandra Norwicka

Sarah Missel

The present disclosure relates to expansion and activation of T cells. In an aspect, the present disclosure relates to expansion and activation of γδ T cells that may be used for transgene expression. In another aspect, the disclosure relates to expansion and activation of γδ T cells while depleting α- and/or β-TCR positive cells. T cell populations comprising expanded γδ T cell and depleted or reduced α- and/or β-TCR positive cells are also provided for by the instant disclosure. The disclosure further provides for methods of using the disclosed T cell populations.

Methods for expanding and activating γσ T cells for the treatment of cancer and related malignancies

The present disclosure relates to expansion and activation of T cells. In an aspect, the present disclosure relates to expansion and activation of &#x3b3;&#x3b4; T cells that may be used for transgene expression. In another aspect, the disclosure relates to expansion and activation of &#x3b3;&#x3b4; T cells while depleting &#x3b1;- and/or &#x3b2;-TCR positive cells. T cell populations comprising expanded &#x3b3;&#x3b4; T cell and depleted or reduced &#x3b1;- and/or &#x3b2;-TCR positive cells are also provided for by the instant disclosure. The disclosure further provides for methods of using the disclosed T cell populations.

Methods for expanding and activating &#x3b3;&#x3b4; T cells for the treatment of cancer and related malignancies

Growing community of inventors

Houston, TX, United States of America

Monique Dao