Octapharma Ag

Monika Stadler

Djuro Josic

Horst Schwinn

Gerhard Gruber

Werner Gehringer

Andrea Buchacher

Frederic Bal

A process for preparing a hemostatically active preparation containing von Willebrand factor (vWF) from a fraction of human plasma by chromatographic purification of a vWF-containing plasma fraction on an anion-exchange material which has the anion-exchanging groups on grafted polymeric structures (tentacle materials), collecting a vWF-containing fraction, followed by purification of said fraction using gel permeation to prepare a purified thermally stable vWF-containing preparation; and heating the preparation for inactivating viruses.

Hemostatically active vWF-containing preparation and process for the preparation thereof

Haemostatically active preparation containing vWF and method for the production thereof

A method for the inactivation of viruses, in particular those having no lipid coats, in protein-containing compositions from blood, blood plasma or similar natural sources by treating said source, simultaneously or succesively, with an effective amount of dialkyl or trialkyl phosphates and optionally surfactants at an elevated temperature in the range of from 55&deg; C. to 67&deg; C. for five hours to 30 hours.

Method for the inactivation of non-lipid-coated viruses

Process for testing suitability of protein fractions containing factor

Process for recovering a high-purity virus-inactivated factor VIII by

Growing community of inventors

Wienerherberg, Austria

Monika Stadler