Council of Scientific and Industrial Research

Monika Singh

Suman Preet Singh Khanuja

Ajit Kumar Shasany

Mahendra Pandurang Darokar

Sushil Kumar

Madan Mohan Gupta

Jai Shankar Arya

Soumya Awasthi

Subhash Chandra Gupta

Vivek Kumar Gupta

Prachi Sinha

Sunil Balkrishna Mansinghka

Suresh Haribhau Dawle

Sweta Agarwal

Ram Kishore Verma

Tiruppadiripuliyur Ranganathan Santha Kumar

Janak Raj Bahl

Dharmendra Saikia

Raj Kishori Lal

Suchi Srivastava

Santosh Kumar Srivastava

Anirban Pal

Laiq Ur Rahman

Subash Chandra Verma

Subhas Chandra Gupta

Ranganathan Santha Kumar Tiruppadiripuliyur

Harpreet Kaur

Arvind Kumar Tripathy

Jai Shanker Arya

The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

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The invention relates to a new use of a non-alkaloid compound that is plant derived glycoside 'glycyrrhizin' as a highly potent bio-enhancer of activity and availability of antibiotics and other drugs including anti-infective and anticancer agents. The molecule of invention facilitates the absorption/uptake of antibiotics and other molecules across the cell membrane in plant and animal cells as well as Gram-positive and Gram-negative bacteria and therefore can be used as a drug facilitator or bioenhancer molecule to increase the affectivity of drugs and nutraceutical agents. The compound having no antimicrobial or cytotoxic activity of its own, is a safe candidate to reduce the drug dosage towards circumventing the problem of drug resistance and the other side effects in anti-infective and anti-cancer therapies.

Use of bioactive fraction from cow urine distillate ('go-mutra') as a bio-enhancer of anti-infective, anti-cancer agents and nutrients

The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods ofThe present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (&#x2212;) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.

Nitrile glycoside useful as a bioenhancer of drugs and nutrients, process of its isolation from moringa oleifera

The present invention relates a hexane bioactive fraction and obtained from the roots of an aromatic plant named commonly found in India for inhibiting the growth of drug resistant bacterial infections in humans and animals; also relates to a pharmaceutical composition comprising the bioactive extract with other additives for inhibiting the growth of drug resistant bacterial infections in humans and animals and a process for the isolation of said bioactive extract

Bioactive hexane fraction from Vetiveria zizanioides

A pharmaceutical composition comprising an antibiotic and cow urine distillate in an amount effective to enhance antimicrobial effect of the antibiotic is disclosed. The antibiotic can be an antifungal agent. The antibiotic can be a quinolone or a fluoroquinolone. The antifungal agent can be azoles, clotrimazole, mystatin or amphotericin.

Pharmaceutical composition containing cow urine distillate and an antibiotic

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Lucknow, India

Monika Singh