Schering Aktiengesellschaft

Monika Lessl

Rolf Bohlmann

Rosemarie Lichtner

Karl-Heinrich Fritzemeier

Yukishige Nishino

Christa Hegele-Hartung

Karsten Parczyk

Hermann Kuenzer

Jorg Kroll

Ulrich Klar

Gerhard Sauer

Helmut Hofmeister

Dirk Kosemund

Ludwig Zorn

Martin Schneider

Nikolaus Heinrich

Bertram Weiss

Hermann Kunzer

Ulf Boemer

Gerd Mueller

Rudolf Knauthe

Michaele Peters-Kottig

Georg Beckmann

Benzocycloheptenes of formula (I), in which R, Rand Y have the meanings that indicated herein, exhibit selective estrogenic activity on bones and are suitable for the production of pharmaceutical agents, especially for prophylaxis and therapy of osteoporosis: 

Benzocycloheptenes, process for their production, pharmaceutical preparations that contain that latter as well as their use for the production of pharmaceutical agents

Two human MATER proteins as well as their use for fertility disorders, therapy and diagnosis are described.

Human mater proteins

The invention describes new compounds as pharmaceutical active ingredients, which have in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo a preferential action on bone rather than the uterus, their production, their therapeutic use and pharmaceutical dispensing forms that contain the new compounds. The new compounds are 16&#x3b1;- and 16&#x3b2;-hydroxy-estra-1,3,5(10)-estratrienes, which carry additional substituents on the steroid skeleton and can have one or more additional double bonds in the B-, C- and/or D-rings.

16-hydroxyestratrienes as selectively active estrogens

This invention relates to new antiestrogens of the general formulain which the substituents have the meanings that are explained in more detail in the description. The new compounds are a) pure antiestrogens or b) antiestrogens with partial estrogenic action (tissue-selective estrogens). Based on these properties, the new compounds are suitable for the production of pharmaceutical agents: in the case of a), for example, for the treatment of breast cancer; in the case of b), for example, for hormone replacement therapy.

Antiestrogens, process for their production and their pharmaceutical use

This invention describes the new benzocycloheptenes of general formula Iin which

Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents

11&bgr;-HALOGEN-7&agr;-SUBSTITUTED ESTRATRIENES, PROCESS FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS THAT CONTAIN THESE 11&bgr;-HALOGEN-7&agr;-SUBSTITUTED ESTRATRIENES AS WELL AS THEIR USE FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS

Antiestrogens, process for their protection and their pharmaceutical use

This invention relates to new antiestrogens of the general formula ##STR1## in which the substituents have the meanings that are explained in more detail in the description. The new compounds are a) pure antiestrogens or b) antiestrogens with partial estrogenic action (tissue-selective estrogens). Based on these properties, the new compounds are suitable for the production of pharmaceutical agents: in the case of a), for example, for the treatment of breast cancer; in the case of b), for example, for hormone replacement therapy.

Growing community of inventors

Berlin, Germany

Monika Lessl