Eyesense Ag

Novartis Ag

Monika Knuth

Achim Müller

Peter Herbrechtsmeier

Katharina Nikolaus

Ralf Pasternack

Jens Zotzel

Achim Mueller

Achim Muller

Christine Reiff

Katharina Schmid

Hans-Lothar Fuchsbauer

Kai Oertel

Christine Reiff, Geb Schmitt

The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to a device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein, wherein the hydrogel comprises a first hydrogel matrix made of alginate and a second hydrogel matrix which forms an interpenetrating network within the first hydrogel matrix. The invention further relates to the use of such a device for determining the glucose content in a sample and to the use of the device for diagnosing impaired glucose metabolism in a test subject.

Device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein

The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.

Use of hydrogels for biosensors having elevated sensitivity

The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.

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An implant () for detecting at least one analyte () in a body fluid, in particular an eye fluid, is proposed. The implant () is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant () having a hydrogel matrix () with at least one hydrogel (). The implant () also has sensor particles () dispersed in the hydrogel matrix (), the sensor particles () having at least one sensor matrix () with a sensor matrix material () and at least one sensor material ().

Hydrogel implant for sensing metabolites in body tissue

The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.

Method for coating silicone hydrogels

The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking the water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.

Growing community of inventors

Aschaffenburg, Germany

Monika Knuth