Hewlett-packard Company

Agilent Technologies, Inc.

Monika Dittmann

Gerard Rozing

Klaus E Witt

Hans-Peter Zimmermann

Klaus K Unger

Friedrich Bek

Thomas Adam

A microfluidic system, particularly a microfluidic chip, with at least one operational channel, in which a fluid and/or the constituents contained therein are moveable in the direction of the operational channel by a driving force, particularly by using pressure, acoustic energy, or an electrical and/or a magnetic field. At least one measurement sensor used to measure a measurable value assigned to the fluid and derivable in the region of the fluid and at least one regulator is provided to regulate the driving force and/or a parameter that may be influenced by it, wherein the regulator is coupled with a measurement sensor and a device used to alter the driving force and/or the parameter that may be influenced by it. The microfluidic system further relates to a procedure to transport and guide a fluid and/or the constituents contained therein within a microfluidic system of the type described above. For this, the regulator regulates the driving force and/or the parameter that may be influenced by it by means of a measurement sensor to measure a parameter assigned to the fluid and derivable in the vicinity of the fluid and by means of a device used to alter the driving force and/or a parameter that may be influenced by it.

Microfluidic system

A column for capillary chromatographic separations, for example high performance liquid chromatography, capillary electrochromatography, or supercritical chromatography, includes a column bed of packing material arranged in the inner bore of the column, and a retainer for retaining the column bed in the interior of the column, wherein the retainer includes regions in the interior of the column having radial dimensions which are different from that of the inner bore. Preferably, the column is a fused silica capillary whose protective layer is removed in a detection area so that sample substances separated in the column can be detected by means of a light source which transmits radiation through the column which is detected by a detector.

Column for capillary chromatographic separations

A column for capillary chromatographic separations, for example high performance liquid chromatography, capillary electrochromatography, or supercritical chromatography, comprises a column bed of packing material arranged in the inner bore of a capillary, wherein said bed of packing material is completely immobilized by a thermal treatment. The thermal treatment preferably comprises moving a heating wire along the column while applying pressure to the column using a high pressure pump.

Column for capillary chromatographic separations and method of

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Marxzell, Germany

Monika Dittmann