University of Exeter

Monika Bokori-Brown

Richard W Titball

Claire Naylor

There is provided an epsilon toxin epitope polypeptide comprising a sequence of at least 10 contiguous amino acids from SEQ ID NO:3, the sequence comprising a mutation of at least one tyrosine residue compared to the equivalent sequence in SEQ ID NO:3, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:5 and having reduced toxicity compared with the toxicity of SEQ ID NO:5. The polypeptide is useful in a method of vaccinating a subject against developing a disease caused byand/or caused by (or associated with the presence of) active epsilon toxin.

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Exeter, United Kingdom

Monika Bokori-Brown