Merial Limited

Massachusetts Institute of Technology

Boehringer Ingelheim Animal Health USA Inc.

Monica Tejwani

Joseph K Rosentel, Jr

Arima Das-Nandy

Jaedeok Yoo

Chen-Chao Wang

Esteban Bornancini

Willie J Roach

Joseph K Rosentel Jr

Jr Joseph K Rosentel

This invention relates to compositions for combating ectoparasites and endoparasites in animals, comprising at least one 1-arylpyrazole, at least one macrocyclic lactone, at least one insect growth regulator, and at least one anthelmintic compound in combination with a pharmaceutically acceptable carrier. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

Parasiticidal compositions comprising multiple active agents, methods and uses thereof

The invention includes a core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and particles of a release-regulating polymer. The shell may be substantially impervious but the release-regulating polymer may become suitable to allow diffusion through it when activated. The core may include a buffer region between the shell and the API-containing portion of the core. The dosage form may include multiple units. The dosage form of the invention is capable of providing a release profile whose time scale can be adjusted by adjusting powder composition, and which may be approximately zero-order release. The invention further includes methods of manufacturing such a dosage form, such as three-dimensional printing.

Diffusion-controlled dosage form and method of fabrication including three dimensional printing

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Monmouth Junction, NJ, United States of America

Monica Tejwani