National Institutes of Health, a Component of the US Dept. of Health & Human Services

Monica R Foote

Dennis J Kopecko

Manuel Osorio

Described herein is the generation of a plasmid construct for expression of aF1-V fusion protein. In the disclosed plasmid, the F1-V fusion protein coding sequence is operably linked to thehtrA promoter, and is fused in-frame to theHlyA secretion signal sequence. Also described isserovar Typhi strain Ty21a containing the F1-V fusion protein expression plasmid, such as for use as an oral vaccine against plague.

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North Potomac, MD, United States of America

Monica R Foote