University of California

Monica Lin

Michel Martin Maharbiz

Jose M Carmena

Dongjin Seo

Chelsea Shields Bahney

Safa Herfat

Meir Marmor

Vivek Subramanian

Ana Claudia Arias

Shuvo Roy

Michael Richard Harrison

Daniel A Cohen

Elisabeth Jacques Leeflang

David M Young

Yasser Khan

Felippe Pavinatto

Sarah Swisher

Amy Liao

Described herein is an implantable device configured to detect impedance characteristic of a tissue. In certain exemplary devices, the implantable device comprises (a) an ultrasonic transducer configured to emit an ultrasonic backscatter encoding information relating to an impedance characteristic of a tissue based on a modulated current flowing through the ultrasonic transducer; (b) an integrated circuit comprising (i) a variable frequency power supply electrically connected to a first electrode and a second electrode; (ii) a signal detector configured to detect an impedance, voltage, or current in a circuit comprising the variable frequency power supply, the first electrode, the second electrode, and the tissue; and (iii) a modulation circuit configured to modulate the current flowing through the ultrasonic transducer based on the detected impedance, voltage, or current; and the first electrode and the second electrode configured to be implanted into the tissue in electrical connection with each other through the tissue. Further described are systems including one or more implantable devices and an interrogator for operating the implantable device, methods of measuring impedance characteristic of a tissue in a subject, and methods of monitoring or characterizing a tissue in a subject.

Implants using ultrasonic backscatter for sensing electrical impedance of tissue

Methods and apparatus for real-time, quantifiable monitoring of high-risk areas of biological tissue are described. The methods and apparatus use impedance spectroscopy to detect subtle changes in tissue health.

Methods and apparatus for monitoring wound healing using impedance spectroscopy

Growing community of inventors

Berkeley, CA, United States of America

Monica Lin